low baseline serum albumin a predictor of anemia in patients on chronic hemodialysis

Authors

behzad heidari department of internal medicine, ayatollah rouhani hospital, babol university of medical sciences, babol, iran

hasan taheri department of internal medicine, ayatollah rouhani hospital, babol university of medical sciences, babol, iran

karimollah hajian-tilaki department of social medicine, babol university of medical sciences, babol, iran

mehdi yolmeh department of internal medicine, shaheed behesti hospital, babol university of medical sciences, babol, iran

abstract

background: inflammatory process has a substantial contribution in the development of anemia in chronic hemodialysis patients. low serum albumin in hemodialysis patients is considered a marker of inflammation. the present longitudinal study aimed to determine the relationship between low baseline serum albumin and future development of anemia. methods: the population of this study consisted of all patients on standard maintenance hemodialysis for at least three months or longer. patients were classified as high or low serum albumin level (≥ or < 3.9 gr/dl). all patients received the standard treatment of anemia. the main objective of this study was to compare the prevalence of anemia defined as hemoglobin levels < 11 gr/dl between the two study groups at the end of the study period. results: a total of 82 patients (50% females) with mean±sd age of 55±16.8 years and mean dialysis duration of 5.2±4 years were followed-up for an average period of 10±1 (range, 8-11) months, however 48 patients with high serum albumin and 24 patients with low serum albumin group completed the study. at baseline, the two groups were similar regarding hemoglobin (9.8±1.2 vs 9.16±1.6 gr/dl, p=0.95) levels. at endpoint, prevalence of anemia in high albumin group was significantly lower than the low albumin group (50% versus 83.3% p=0.005). conclusion: the findings of this study indicate that low serum albumin in hemodialysis patients is a predictor of anemia indicating unresponsiveness to conventional treatment of anemia.

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Journal title:
caspian journal of internal medicine

جلد ۶، شماره ۳، صفحات ۱۶۱-۱۶۴

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